REPRODUCTIVE HEALTH OF MEN WITH CHRONIC INFLAMMATION OF THE UROGENITAL TRACT

Authors

DOI:

https://doi.org/10.32782/city-development.2024.3-16

Keywords:

reproductive health, chronic inflammation of the urogenital tract of male, mathematical modeling

Abstract

The aim of the study was to statistically evaluate the impact of chronic inflammation of the urogenital tract and other related factors on men's reproductive health, as well as predicting the likelihood of future health. The study was implemented in several successive stages. In the first stage, a system of key indicators of the impact on men's reproductive health due to the transfer of chronic inflammation of the urogenital tract (CIUT) was developed by expert interrogation of family doctors, dermatovenereologists, urologists. In the second stage, information on key factors of influence was collected by interviewing men during 2021-2024 by the face-to-face method during the admission of patients to the clinical bases of the Department of Family Medicine and outpatient care at the NMAPE named after P.L. Shupik. 422 patients participated in the survey. In the third stage, on the basis of the formed database of the interviewed patients, the correlation between the reproductive health indicator of men with CIUT and the main factors that determine it is established. In the next stage, factor variables were identified and prognostic models of the probability of fertility decline among men with CIUT were constructed. The system of key indicators for the impact on men's reproductive health due to the transfer of CIUT is grouped into five blocks: socio-demographic characteristics; history of sexual system diseases; maintaining a healthy lifestyle; features of sexual life; actual semen parameters. The greatest impact on the negative reproductive health of men who have a history of stroke has demographic characteristics of patients and sperm parameters. Thus, men over 40 years of age with a pathological sperm morphotype are more likely to have a decrease in fertility in the background or after treatment with CIUT. In the course of the experimental calculations, it was found that the most appropriate approach in identifying the factors influencing the future reproductive health of men is to use linear prognostic models using structural variables. When constructing a prognostic model of men's reproductive health, it was determined that the model was more adequate when combining the factors of each of the five indicator blocks. As a result of identifying the most important factor variables for their further use in the prognostic models of men's reproductive health, a stepwise regression method with “joining” and “exclusion” was applied.

References

Zakon Ukrainy dated November 19, 1993 No. 2801-XII-VR "Osnovy zakonodavstva Ukrainy pro ochoronu zdoroviya" [Law of Ukraine dated November 19, 1993 No. 2801-XII -VR "The Fundamentals of Ukrainian Legislation on Health Care"]. Available at: https://zakon.rada.gov.ua/laws/show/157-19#Text

Order of the Ministry of Health of Ukraine dated March 19, 2015, No. 504 "On Approval of the Procedure for Provision of Primary Health Care".

Verbets V. V. (2006) Methodology and method of sociological research: Educational and methodical manual. The second ed. Rivne: RDU: Institute for Social Studies, 168 p.

Gorpinichenko I. I., Poroshyna T. V. et al. (2009) Chronic abacterial prostatitis: Immunological study of ejaculate. Health of the man. vol. 2. pp. 80–82.

Demchenko A. N. (2004) Dysfunctional hypofertility in men, the latest approaches to its classification, diagnosis and therapy. News of medicine and pharmacy. vol. 13. pp. 16–18.

Lyahg Y., Guriyanov V. G. (2004) Fundamentals of Computer Biostatistics: Analysis of Information in Biology, Medicine and Pharmacy by the Statistical Package of MedStat. 212 p.

Tiktinski S. L. (1990) Andrology Guide.

Tkach E. I., Storozhuk V. P. (2009) General theory of statistics: textbook for the student. higher teach eng. Kyiv: Center for Educational Literature. 442 p.

Azenabor A/, Oloruntoba Ekun A/, Akinloye O. (2015) Impact of Inflammation on Male Reproductive Tract. J Reprod Infertil. vol. 16 (3). pp. 123–129.

Baker P., Shand T. (2017) Men’s health: time for a new approach to policy and practice? J Glob Health, no. 7.

Glazer C. H., Bonde J. P., Eisenberg M. L., Giwercman A., Hærvig K. K., Rimborg S., Vassard D. et al. (2017) Male infertility and risk of nonmalignant chronic diseases: a systematic review of the epidemiological evidence. Semin Reprod Med. vol. 35 p. 282–290.

Hollanders J. M. G., Carver-Wand J. A. (1996) Male Infertility - from A to Z. 94 p.

Levine H., Jørgensen N., Martino-Andrade A., Mendiola J., Weksler-Derri D., Mindlis I., Pinotti R., Swan S. H. (2017) Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update. vol. 23. pp. 646–649.

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Published

2024-10-11

How to Cite

Tsiporenko, S., & Kovalenko, O. (2024). REPRODUCTIVE HEALTH OF MEN WITH CHRONIC INFLAMMATION OF THE UROGENITAL TRACT. CITY DEVELOPMENT, (3 (03), 117–123. https://doi.org/10.32782/city-development.2024.3-16

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